N-heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals.
نویسندگان
چکیده
An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
منابع مشابه
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 137 7 شماره
صفحات -
تاریخ انتشار 2015